Assailants surprise you Edit
You are working outside and assailants surprise you forcing you inside your home. There is a specific room that holds the safe which you never enter before either phoning the security company or entering a code. The robbers ransack the house and opens this door. Since you did not indicate you would enter it, an alarm signal is sent via DsLam, MeshNetworking or GpsAndGprs.
Or install a small safe inside a cupboard. The safe should never be opened because on opening the safe a sensor is triggered sending out a panic signal. We have completely rethink how we go about our business in this country. Every single valuable item from a vehicle to a television should be tagged with either a GSM modem, Zigbee , RFID or Bluetooth RadioModems that is in 24hour communication with a base in our attempt at implementing http://scratchpad.wikia.com/wiki/NetworkCentricWarfare
Dig a hole for the safe Edit
Use a jackhammer to dig a hole for the safe. Pour concrete and secure top of safe level with the floor.
Motor actuated steel lid Edit
Build a steel cage into which the safe is bolted, level with the ground. The top of the cage can only be opened via motor actuation and not a key for the specific reason that if anybody gets hold of the key they can open the safe. See http://sasecurity.wikia.com/wiki/Cnc_electronics#z-axis You need both the key and an electronic signal to get to the actual safe below the steel lid. A vibration sensor detects an attempt to cut through the steel with an angle grinder. A light sensor detects a blowtorch cutting through the steel lid. These sensors and motor interfaces with a RS485 , ["RS485"] circuit. Actuating the motor needs a code to be entered. Should you be under duress than a duress signal can be sent.
Vibration sensor Edit
See CompHomeAutomation for vibration sensors that will detect an attempt at breaking into a safe. But I am not so sure it will detect a cutting torch. To detect this us an ultraviolet detection sensor must be used from BoMarc.